Defining control coefficients in non-ideal metabolic pathways
نویسندگان
چکیده
منابع مشابه
Defining control coefficients in non-ideal metabolic pathways.
The extent to which an enzyme controls a flux has been defined as the effect on that flux of a small modulation of the activity of that enzyme divided by the magnitude of the modulation. We here show that in pathways with metabolic channelling or high enzyme concentrations and conserved moieties involving both enzymic and non-enzymic species, this definition is ambiguous; the magnitude of the c...
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The control structure of a metabolic system can in principle be determined without the need for purification of the component enzymes and study of their kinetic properties, provided that their activities can be perturbed by amounts sufficient to produce measurable changes in the steady-state variables, i.e. the fluxes through the system and the concentrations of the intermediates. Each perturba...
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ژورنال
عنوان ژورنال: Biophysical Chemistry
سال: 1995
ISSN: 0301-4622
DOI: 10.1016/0301-4622(95)00039-z